Impenetrable Tumors and Untargetable Cancers: Engineering Nanocarrier Tools and Delivery Strategies to do the (apparently) Impossible

Stavroula Sofou from Johns Hopkins University

Sofou’s team aims to improve the therapeutic potential of chemotherapy and of alpha-particle radiotherapy to solid tumors by applying delivery strategies to overcome transport limitations in diffusion-limited environments.

Sofou’s team uses primarily model lipid membranes, in the form of lipid vesicles, as drug delivery carriers, with the aim to precisely control their interactions with the tumor microenvironment increasing therapeutic efficacy while minimizing toxicities.

To engineer lipid vesicles with properties useful to drug delivery, her team studies phase-separated lipid domains to direct the vesicles’ surface topography and functionality, and the vesicles’ membrane permeability and fusogenicity.