Publications
1. P.G. Vekilov, Elementary processes of protein crystal growth, in Studies and Concepts in Crystal Growth, edited by H. Komatsu (Pergamon Press, Oxford, 1993) pp. 25-49.
2. P.G. Vekilov, Cover Picture and Story, in Advances in Crystal Growth Research, edited by K. Sato, Y. Furukawa, and K. Nakajima. (Elsevier, Amsterdam, 2001).
3. P.G. Vekilov and A.A. Chernov, The Physics of Protein Crystallization, in Solid State Physics, vol. 57, edited by H. Ehrenreich and F. Spaepen (Academic Press, New York, 2002) pp. 1-147.
4. O. Gliko and P. G. Vekilov, Spatio-Temporal Patterns in Ferritin Crystal Growth, in Biological and Biomimetic Materials – Properties to Function, edited by J. Aizenberg, J.M. McKitrick and C.A. Orme, (MRS, Warrendale, PA., 2002) pp. 141-146
5. P.G. Vekilov, A. Feeling-Taylor and R. Elison Hirsch, Nucleation and growth of crystals of hemoglobins: case of HbC, in Methods in Hemoglobin Disorders, Series in Molecular Medicine, edited by R.L. Nagel (Humana Press, Totowa, NJ, 2003).
6. P.G. Vekilov, Solvent entropy effects in the formation of protein solid phases, in Methods in Enzymology volume 368: Macromolecular Crystallography, Part C edited by C.W. Carter, Jr., and R.M. Sweet, (Academic Press, San Diego, 2003) pp. 84-105.
7. P.G. Vekilov, Molecular mechanisms of defect formation, in Methods in Enzymology volume 368: Macromolecular Crystallography, Part C edited by C.W. Carter, Jr., and R.M. Sweet (Academic Press, San Diego, 2003) pp. 170-188.
8. J.J. De Yoreo, P.G. Vekilov, Principles of crystal nucleation and growth, in Biomineralization edited by P.M. Dove, J.J. De Yoreo, S. Weiner (Mineral Soc. Am., Washington, DC, 2003) pp. 57-93
9. P.G. Vekilov, Microscopic, mesoscopic, and macroscopic lengthscales in the kinetics of phase transformations with proteins, in Nanoscale Structure and Assembly at Solid-fluid Interfaces, edited by J.J. De Yoreo and X.Y. Lui (Kluwer Press, New York, 2004) pp. 145-200.
10. P.G. Vekilov and O. Galkin, Fundamental aspects of nucleation theory revealed in experiments with protein solid phases, in Nanoscale Structure and Assembly at Solid-fluid Interfaces, edited by X.Y. Lui and J.J. De Yoreo (Kluwer Press, New York, 2004) pp. 105-144.
11. P.G. Vekilov, Kinetics and mechanisms of protein crystallization at the molecular level, in Methods in Molecular Biology, vol. 300: Protein Nanotechnology, Protocols, Instrumentation, and Applications, edited by T. Vo-Dinh (Humana Press, Totowa, NJ, 2005) pp. 15-52.
Review papers
12. P.G. Vekilov and J.I.D. Alexander, Dynamics of layer growth in protein crystallization, Chem. Rev. 100 (2000) 2061-2089.
13. P.G. Vekilov, Self-Assembly of Apoferritin Molecules into Crystals: Thermodynamics of Molecular Level Processes, Progress in Crystal Growth and Characterization of Materials 45 (2002) 175-199.
14. P.G. Vekilov, Dense liquid precursor for the nucleation of ordered solid phases from solution, Crystal Growth and Design, 4 (2004) 671-685.
Papers in refereed journals
15. Yu.G. Kuznetsov, A.A. Chernov, P.G. Vekilov and I.L. Smol'skii, Kinetics of growth of (101) faces of NH4H2PO4 crystals from aqueous solutions. Sov. Phys.-Crystallogr. 32 (1987) 584-587.
16. P.G. Vekilov, Yu.G. Kuznetsov and A.A. Chernov, Dissolution morphology and kinetics of (101) ADP face; mild etching of possible surface defects. J. Crystal Growth 102 (1990) 706-716.
17. P.G. Vekilov and Yu.G. Kuznetsov, Growth kinetics irregularities due to changed dislocation source activity; (101) ADP face. J. Crystal Growth 119 (1992) 248-260.
18. P.G. Vekilov, Yu.G. Kuznetsov and A.A. Chernov, The effect of temperature on step motion; (101) ADP face. J. Crystal Growth 121 (1992) 44-52.
19. P.G. Vekilov, Yu.G. Kuznetsov and A.A. Chernov, Interstep interaction in solution growth; (101) ADP face. J. Crystal Growth 121 (1992) 643-655.
20. P.G. Vekilov and Chr. Nanev, Elementary growth kinetics of silver electrocrystallization. J. Crystal Growth 125 (1992) 229-236.
21. P.G. Vekilov, Yu.G. Kuznetsov and A.A. Chernov, Elementary growth mechanism of dipyramid ADP face. Ferroelectrics 142 (1993) 145-152.
22. P.G. Vekilov, M. Ataka and T. Katsura, Laser Michelson Interferometry investigation of protein crystal growth. J. Crystal Growth 130 (1993) 317-320.
23. P.G. Vekilov, M. Ataka and T. Katsura, Growth processes of protein crystals revealed by laser Michelson interferometry investigation. Acta Crystallogr. D51 (1995) 207-219.
24. P.G. Vekilov, L.A. Monaco and F. Rosenberger, High-resolution interferometric technique for in-situ studies of crystal growth morphologies and kinetics. J. Crystal Growth 146 (1995) 289-296.
25. P.G. Vekilov, L.A. Monaco and F. Rosenberger, Facet morphology response to non-uniformities in nutrient and impurity supply. I. Experiments and interpretation. J. Crystal Growth, 156 (1995) 267-278.
26. P.G. Vekilov and F. Rosenberger, Dependence of lysozyme growth kinetics on step sources and impurities. J. Crystal Growth 158 (1996) 540-551.
27. H. Lin, P.G. Vekilov and F. Rosenberger, Facet morphology response to non-uniformities in nutrient and impurity supply. II. Numerical modeling. J. Crystal Growth 158 (1996) 552-559.
28. B.R. Thomas, P.G. Vekilov and F. Rosenberger, Heterogeneity determination and purification of commercial hen egg white lysozyme. Acta Crystallogr. D52 (1996) 776-784.
29. P.G. Vekilov, L.A. Monaco, B.R. Thomas, V. Stojanoff and F. Rosenberger, Repartitioning of NaCl and protein impurities in lysozyme crystallization. Acta Crystallogr. D52 (1996) 785-798.
30. F. Rosenberger, P.G. Vekilov, M. Muschol and B.R. Thomas, Nucleation and crystallization of globular proteins - What do we know and what is missing? J. Crystal Growth, 167 (1996) 1-27.
31. P.G. Vekilov, J.I.D. Alexander and F. Rosenberger, Nonlinear response of layer growth dynamics in the mixed kinetics-bulk transport regime. Phys. Rev. E 54 (1996) 6650-6660.
32. P.G. Vekilov, H. Lin and F. Rosenberger, Unsteady crystal growth due to step-bunch cascading. Phys. Rev. E 55 (1997) 3202-3214.
33. V. Stojanoff, D.P. Siddons, L.A. Monaco, P.G. Vekilov and F. Rosenberger, X-ray topography of tetragonal lysozyme grown by the temperature controlled technique. Acta Crystallogr. D53 (1997) 588-595.
34. F. Rosenberger, P.G. Vekilov, H. Lin and J.I.D. Alexander, A rationale for system-dependent advantages and disadvantages of solution crystal growth at low gravity. Microgravity Sci. Tech., 10 (1997) 29-35.
35. B.R. Thomas, P.G. Vekilov and F. Rosenberger, Effects of microheterogeneity on hen egg white lysozyme crystallization. Acta Crystallogr. D54 (1998) 226-236.
36. P.G. Vekilov and F. Rosenberger, Protein crystal growth under forced solution flow: experimental setup and general response of lysozyme. J. Crystal Growth 186 (1998) 251-261.
37. P.G. Vekilov and F. Rosenberger, Increased stability in crystal growth kinetics in response to bulk transport enhancement. Phys. Rev. Lett. 80 (1998) 2654-2656.
Featured in Science vol. 285August 6, 1999, p. 835
38. P.G. Vekilov and F. Rosenberger, Intrinsic kinetics fluctuations as cause of growth inhomogeneity in protein crystals. Phys. Rev. E 57 (1998) 6979-6981.
39. P.G. Vekilov, B.R. Thomas and F. Rosenberger, Effects of convective solute and impurity transport on protein crystal growth. J. Phys. Chem. 102 (1998) 5208-5216.
40. P.G. Vekilov, F. Rosenberger, H. Lin and B.R. Thomas, Nonlinear dynamics of layer growth and consequences for protein crystal perfection, J. Crystal Growth 196 (1999) 261-275.
41. D.C. Carter, K. Lim, J.X. Ho, B.S. Wright, P.D. Twigg, T.Y. Miller, J. Chapman, K. Keeling, J. Ruble, P.G. Vekilov, B.R. Thomas, F. Rosenberger and A.A. Chernov, Lower dimer impurity incorporation may result in higher perfection of HEWL crystal grown in mg. A case study. J. Crystal Growth 196 (1999) 623-637.
42. F. Rosenberger, H. Lin and P.G. Vekilov, Finite-amplitude instability in growth step trains with overlapping step supply fields. Phys. Rev. E 59 (1999) 3155-3164.
43. R. Feeling-Taylor, R. M. Banish, R. Elison Hirsch and P.G. Vekilov, Miniaturized scintillation technique for protein solubility determinations, Rev. Sci. Instr. 70 (1999) 2845-2849.
44. O. Galkin and P.G. Vekilov, Direct determination of the nucleation rates of protein crystals J. Phys. Chem. 103 (1999) 10965-10971.
45. M. Wang, X.-B. Yin, P.G. Vekilov, R.-W. Peng and N.B. Ming, Intrinsic stability of concentration field in diffusion limited growth and its effects on crystallization. Phys. Rev. E 60 (1999) 1901-1905.
46. P.G. Vekilov, Protein crystal growth – microgravity aspects. Advances in Space Research 24 (1999) 1231-1240.
47. O. Galkin and P.G. Vekilov, Are nucleation kinetics of protein crystals similar to those of liquid droplets? J. Am. Chem. Soc. 122 (2000) 156-163.
48. D.N. Petsev and P.G. Vekilov, Evidence for non-DLVO hydration interactions in solutions of the protein apoferritin. Phys. Rev. Lett. 84 (2000) 1339-1342.
49. D.N. Petsev, B.R. Thomas, S.-T. Yau and P.G. Vekilov, Interactions and aggregation of apoferritin molecules in solution: Effects of added electrolyte. Biophysical J. 78 (2000) 2060-2069.
50. B.R. Thomas, A.A. Chernov, P.G. Vekilov and D.C. Carter, Distribution coefficients on protein impurities in ferritin and lysozyme crystals. Self-purification in microgravity. J. Crystal Growth 211 (2000) 149-156.
51. O. Galkin and P.G. Vekilov, Control of protein crystal nucleation around the metastable liquid-liquid phase boundary, Proc. Natl. Acad. Sci. USA 97 (2000) 6277–6281.
52. S.-T. Yau, B.R. Thomas and P.G. Vekilov, Molecular mechanisms of crystallization and defect formation. Phys. Rev. Lett. 85 (2000) 353-356.
53. S.-T. Yau and P.G. Vekilov, Quasi-planar nucleus structure in apoferritin crystallisation. Nature 406 (2000) 494-497.
Featured in Nature, vol. 406, August 3, 2000, p. 464
Science News, August 5, 2000, p. 84
naturalSCIENCE, News, August 3, 2000
Microgravity News, vol. 7 #3, Fall 2000, p.11
54. R. E. Hirsch., R.E. Samuel, N.A Fataliev, M.J. Pollack, O. Galkin, P.G. Vekilov, and R.L. Nagel, Differential pathways in oxy and deoxy HbC aggregation/crystallization. Proteins 42 (2000), 99-107.
55. S.-T. Yau, D.N. Petsev, B.R. Thomas, and P.G. Vekilov, Molecular-level thermodynamic and kinetic parameters for the self-assembly of apoferritin molecules into crystals. J. Mol. Biol. 303 (2000) 667-678.
56. H. Lin, D.N. Petsev, S.-T. Yau, B.R. Thomas and P.G. Vekilov, Lower incorporation of impurities in ferritin crystals by suppression of convection: modeling results, Crystal Growth and Design 1 (2001) 73-79
invited paper for inaugural issue of Crystal Growth and Design
57. S.-T. Yau and P.G. Vekilov, Direct observation of nucleus structure and nucleation pathways, J. Am. Chem. Soc. 123 (2001) 1080-1089.
58. S.-T. Yau, B.R. Thomas, O. Galkin, O. Gliko, and P.G. Vekilov, Molecular mechanisms of microheterogeneity-induced defect formation in ferritin crystallization, Proteins 43 (2001) 343-352.
59. M.D. Serrano, O. Galkin, S.-T. Yau, B.R. Thomas, R.L. Nagel, R. E. Hirsch, and P.G. Vekilov, Are protein crystallization mechanisms relevant to understanding and control of polymerization of deoxyhemoglobin S? J. Crystal Growth 232 (2001) 368-375.
60. O. Galkin and P.G. Vekilov, Nucleation of protein crystals: critical nuclei, phase behavior, and control pathways. J. Crystal Growth 232 (2001) 63-76.
61. S.-T. Yau, B.R. Thomas,and P.G. Vekilov, Real time, in-situ, monitoring of apoferritin crystallization and defect formation with molecular resolution. J. Crystal Growth 232 (2001) 188-194.
62. D.N. Petsev, B.R. Thomas, S.-T. Yau, D. Tsekova, C.N. Nanev, W.W. Wilson, and P.G. Vekilov, Temperature-independent solubility and interactions between apoferritin monomers and dimers in solution. J. Crystal Growth 232 (2001) 27-29.
63. O. Galkin, K. Chen, R.L. Nagel, R.E Hirsch, P.G. Vekilov, Liquid-liquid separation in solutions of normal and sickle cell hemoglobin, Proc. Natl. Acad. Sci. USA 99 (2002) 8479–8483.
64. N. A. Booth, A. A. Chernov, P.G. Vekilov, Characteristic lengthscales of step bunching in KDP crystal growth: in-situ differential phase-shifting interferometry study. J. Crystal Growth 237-239 (2002), 1818-1824.
65. P.G. Vekilov, A.R. Feeling-Taylor, D.N. Petsev, O. Galkin, R.L. Nagel, R. E. Hirsch, Intermolecular Interactions, Nucleation and Thermodynamics of Crystallization of Hemoglobin C. Biophys. J. 83 (2002) 1147-1156.
Featured on the cover of Science vol. 299 #5609 February 14, 2003
66. N. A. Booth, A. A. Chernov, P.G. Vekilov, Step Bunching in KDP Crystal Growth: Phenomenology, J. Materials Research 17 (2002) 2059-2065.
67. K. Chen and P.G. Vekilov, Evidence for the surface diffusion mechanism of solution crystallization from molecular-level observations. Phys. Rev. E 66 (2002) 021606.
68. O. Gliko, N. A. Booth, E. Rosenbach, P. G. Vekilov, Phase-shifting interferometry for the study of the step dynamics during crystallization of proteins. Crystal Growth and Design 2 (2002)381-385.
69. P. G. Vekilov, A. R. Feeling-Taylor, S.-T. Yau, and D. Petsev, Solvent entropy contribution to the free energy of protein crystallization, Acta Crystallogr. Section D. 58 (2002) 1611-1616.
70. O. Gliko, N. A. Booth, P. G. Vekilov, Step bunching in a diffusion-controlled system: phase-shifting interferometry investigation of ferritin. Acta Crystallogr. Section D. 58 (2002) 1622-1627.
71. N.A. Booth, B. Stanojev, A.A. Chernov, P.G. Vekilov, Differential phase-shifting interferometry for in situ surface characterization during solution growth of crystals, Rev. Sci. Intsr. 73 (2002) 3540-3545.
72. O. Gliko and P. G. Vekilov, Spatio-temporal step patterns during crystal growth in a transport controlled system, J. Phys. Chem., 106 (2002) 11800 – 11804.
73. D.N. Petsev, K. Chen, O. Gliko, and P.G. Vekilov, Diffusion-limited kinetics of the solution-solid phase transition of molecular substances, Proc. Natl. Acad. Sci. USA 100 (2003) 792-796.
74. P.G. Vekilov and O. Galkin, On the methods of determination of homogeneous nucleation rates of protein crystals, Colloids and Surfaces A, 215 (2003) 125-130.
75. H. Lin, S.-T. Yau and P.G. Vekilov, Dissipating step bunches during crystallization under transport control, Phys. Rev. E, 67 (2003) 0031606.
76. D.N. Petsev, X. Wu, O. Galkin and P.G. Vekilov, Thermodynamic functions of concentrated protein solutions from phase equilibria, J. Phys. Chem. B 107 (2003) 3921-3926.
77. O. Gliko, I. Reviakine, P.G. Vekilov, Stable equidistant step trains during crystallization of insulin, Phys. Rev. Lett. 90 (2003) 225503.
Featured inPhysics News Update 636 #2, May 7, 2003
78. I. Reviakine, D.K. Georgiou, P.G. Vekilov Capillarity effects on crystallization kinetics: insulin. J. Am. Chem. Soc. 125 (2003) 11684-11693.
79. .L. Bergeron, L. Filobelo, O. Galkin, P.G. Vekilov, Thermodynamics of the hydrophobicity in crystallization of insulin, Biophys. J. 85 (2003) 3935–3942.
80. O. Galkin and P.G. Vekilov, Mechanisms of homogeneous nucleation of polymers of sickle cell anemia hemoglobin in deoxy-state, J. Mol. Biol. 336 (2004) 43–59.
Featured on cover of J. Mol. Biol. Vol. 336 Number 1, Feb. 6, 2004
81. N.A. Booth, A.A. Chernov, P.G. Vekilov, Interplay of impurities and solution flow as determinants of step patterns dynamics, Phys. Rev. E 69 (2004) 011604.
82. Q. Chen, P.G. Vekilov , R.L. Nagel, and R.E. Hirsch, Liquid-liquid separation in hemoglobins: distinct aggregation mechanisms of the b6 mutants. Biophys. J. 86 (2004) 1702-1712.
83. A.R. Feeling-Taylor, S.-T. Yau, D.N. Petsev, R.L. Nagel, R. E. Hirsch,P.G. Vekilov, Crystallization mechanisms hemoglobin C in the R-state. Biophys. J., 87 (2004) 2621-2629.
84. M. Shah, O. Galkin, and P.G. Vekilov, Smooth transition from metastability to instability in phase separating protein solutions. J. Chem. Phys. 121 (2004) 7505-7512.
85. Y. Qutub, I. Reviakine, C. Maxwell, J. Navarro, E. Landau, and P.G. Vekilov, Mechanisms of in cubo of growth and defect formation of three-dimensional bacteriorhodopsin crystals, J. Mol. Biol. 343, (2004) 1243-1254.
86. A.A. Chernov, J.J. De Yoreo, L.N. Rashkovich and P.G. Vekilov, Step and kink dynamics in inorganic and protein crystallization, MRS Bulletin 29 (2004) 927-934.
87. N.A. Booth, T. Land, P. Erhmann, P.G. Vekilov, The aspect ratio of potassium di-deuterium phosphate (DKDP) crystals. Crystal Growth And Design, 5 (2005) 105-110.
88. P.G. Vekilov, Two-step mechanism for the nucleation of crystals from solution, J. Crystal Growth (2004) in print.
89. A.A. Chernov, L.N. Rashkovich and P.G. Vekilov, Steps in solution growth: dynamics of kinks, bunching and turbulence. J. Crystal Growth (2004) in print.
90. O. Gliko, N. Neumaier, M. Fischer, I. Haase., A. Bacher, S. Weinkauf, P.G. Vekilov, Dense liquid droplets as a step source for the crystallization of lumazine synthase, J. Crystal Growth (2004) in print.
91. A. Penkova, O. Gliko, I.L. Dimitrov, F.V. Hodjaoglu, C. Nanev, and P.G. Vekilov, Enhancement and suppression of protein crystal nucleation due to electrically-driven convection, J. Crystal Growth (2004) in print.
92. O. Gliko, N. Neumaier, W. Pan, M. Fischer, I. Haase., A. Bacher, S. Weinkauf, P.G. Vekilov, A metastable prerequisite for the growth of lumazine synthase crystals, J. Amer. Chem. Soc. (2005) in print.
93. W. Pan, A.B. Kolomeisky, and P.G. Vekilov, Nucleation of ordered solid phases of proteins via a disordered high-density state: phenomenological approach, J. Chem. Phys. (2004) accepted.
94. S. Brandon and P.G. Vekilov, Multiple extrema in the intermolecular potential and the phase diagram of protein solutions, Phys. Rev. E. (2005) submitted.
95. L.F. Filobelo, O. Galkin, and P.G. Vekilov, Spinodal for the solution to crystal phase transformation. J. Phys. Chem. (2005) submitted.
96. N.A. Booth, A.A. Chernov, P.G. Vekilov, Limiting step bunch height in growth of single crystals due to solution turbulence. (2004) submitted.
97. D.K. Georgiou and P.G. Vekilov, A fast response mechanism for insulin storage in crystals may involve a novel mode of kink generation, submitted (2004).
98. O. Gliko, N. Neumaier, W. Pan, S. Weinkauf, P.G. Vekilov, Metastable liquid clusters in supersaturated and undersaturated protein solutions. Nanotechnology (2005) submitted.
99. P.G. Vekilov and F. Rosenberger, High-resolution in-situ interferometric studies of lysozyme crystal growth. Proceedings of the AIAA 1995 Space Programs and Technologies Conference and Exhibit, Huntsville, AL, USA, AIAA-95-3579.
100. H. Lin, P.G. Vekilov and F. Rosenberger, Modeling mass transport and surface kinetics of protein crystals growth. Proceedings of the AIAA 1995 Space Programs and Technologies Conference and Exhibit, Huntsville, AL, USA, AIAA-95-3581.
101. F. Rosenberger, P.G. Vekilov, H. Lin and J.I.D. Alexander, A rationale for system-dependent advantages and disadvantages of solution crystal growth at low gravity. Proceedings of the AIAA 1997 Space Programs and Technologies Conference and Exhibit, Reno, NE, USA, AIAA-97-XXX
102. A.A. Chernov, P.G. Vekilov, S.R. Coriell, B.T. Murray and G.B. McFadden, Step Bunching: Influence of Impurities and Solution Flow. Proceedings of the NASA Microgravity Materials Science Conference, July 14-16, 1998, Huntsville, AL, NASA/CP-1999-209092, pp. 115-124.