Dr. Akhil Bidani
Dunn Professor of Biomedical Engineering
Professor of Chemical & Biomolecular Engineering


Dept. of Chemical and Biomolecular Engineering
University of Houston
4800 Calhoun Ave.
Houston, TX 77204-4004
Office Location: W206, Engr. Bldg. D3
Telephone: (713) 743-4066
E-mail: abidani "at-sign" uh "dot" edu

EDUCATION

—B.S. Chemical Engineering, Punjab University (1969)
—Ph.D. Chemical Engineering, University of Houston (1975)
—M.D., University of Texas Medical Branch (1981)

RESEARCH INTERESTS

› Mechanisms and kinetics of microvascular gas and ion transport
› Intracellular pH and its regulation in lung cells
› Mechanisms of pulmonary uptake of toxic reactive gases
› Pathophysiology of lung function abnormalities in acute lung injury and ARDS
› Physiology of cardiopulmonary support
› Mathematical modeling of cellular transport processes

› back to top

Memberships

—American Academy of Sleep Medicine
—American Association for Bronchology
—American Association for Respiratory Care
—American College of Chest Physicians
—American College of Critical Care Medicine
—American College of Physicians
—American Heart Association, Cardiopulmonary Council
—American Institute of Chemical Engineering
—American Medical Association
—American Physiological Society
—American Society for Artifical Internal Organs
—American Society of Clinical Investigation
—American Thoracic Society
—Biomedical Engineering Society
—European Society for Respiratory Physiology
—Foundation for Critical Care
—Galveston County Medical Association
—Houston Society for Engineering in Medicine and Biology
—New York Academy of Sciences
—Society for Computer Simulation (SCS)
—Society for Critical Care Medicine
—Society for Leukocyte Biology
—Society of General Physiologists
—Southern Society for Clinical Investigation
—Texas Medical Association
—Texas Thoracic Society
—World Association for Bronchology

› back to top

Funding Received

National Institutes of Health (NIH), 1 R01 HL51421-01A2, ALVEOLAR MACROPHAGE INTRACELLULAR ACID BASE REGULATION AND CELL FUNCTION, $228932, 1995-1999

› back to top

SELECTED PUBLICATIONS

1. Jayroe JB, Wang D, Deyo DJ, Alpard SK, Bidani A, Zwischenberger JB. The effect of augmented hemodynamics on blood flow during arteriovenous carbon dioxide removal. Asaio Journal (American Society for Artificial Internal Organs : 1992). 49(1): 30-4, 2003
2. Heming TA, Bidani A. Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange. Immunobiology. 207(2): 141-8, 2003
3. Heming TA, Bidani A. Plasmalemmal H+ extruders in mammalian alveolar macrophages. Comparative Biochemistry and Physiology. A: Molecular and Integrative Physiology. 133(1): 143-50, Sep 2002
4. Morrison RJ, Bidani A. Acute respiratory distress syndrome epidemiology and pathophysiology. Chest Surgery Clinics of North America. 12(2): 301-23, May 2002
   Badar T, Bidani A. Mechanical ventilatory support. Chest Surgery Clinics of North America. 12(2): 265-99, vi, May 2002
5. Alpard SK; Duarte AG; Bidani A; Zwischenberger JB. Pathogenesis and management of respiratory insufficiency following pulmonary resection.. Seminars in Surgical Oncology. 18(2): 183-96, 2000
6. Alpard SK; Zwischenberger JB; Tao W; Deyo DJ; Bidani A. Reduced ventilator pressure and improved P/F ratio during percutaneous arteriovenous carbon dioxide removal for severe respiratory failure.. Annals of Surgery. 230(2): 215-24, Aug 1999
7. Zwischenberger JB; Alpard SK; Bidani A. Early complications. Respiratory failure.. Chest Surgery Clinics of North America. 9(3): 543-64, viii, Aug 1999
8. Niranjan SC; Bidani A; Ghorbel F; Zwischenberger JB; Clark JW Jr. Theoretical study of inspiratory flow waveforms during mechanical ventilation on pulmonary blood flow and gas exchange.. Comput Biomed Res. 32(4): 355-90, Aug 1999
9. Zwischenberger JB; Alpard SK; Conrad SA; Johnigan RH; Bidani A. Arteriovenous carbon dioxide removal: development and impact on ventilator management and survival during severe respiratory failure. Perfusion. 14(4): 299-310, Jul 1999
10. Zwischenberger JB; Conrad SA; Alpard SK; Grier LR; Bidani A. Percutaneous extracorporeal arteriovenous CO2 removal for severe respiratory failure.. Annals of Thoracic Surgery. 68(1): 181-7, Jul 1999
11. Zwischenberger JB; Tao W; Bidani A. Intravascular membrane oxygenator and carbon dioxide removal devices: a review of performance and improvements.. ASAIO Journal. 45(1): 41-6, Jan 1999
12. Bidani A; Hawkins HK; Wang CZ; Heming TA. Dose dependence and time course of smoke inhalation injury in a rabbit model.. Lung. 177(2): 111-22, 1999
13. Alpard S K;Bidani A;Conrad S A;Zwischenberger J B. Arteriovenous carbon dioxide removal.. Asaio Journal. 44(3): 223-4, May 1998
14. Liu C H;Niranjan S C;Clark J W Jr;San K Y;Zwischenberger J B;Bidani A. Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung.. Journal of Applied Physiology. 84(4): 1447-69, Apr 1998
15. Cardenas V Jr;Heming T A;Bidani A. Kinetics of CO2 excretion and intravascular pH disequilibria during carbonic anhydrase inhibition.. Journal of Applied Physiology. 84(2): 683-94, Feb 1998
16. Morrison R J;Singhal S S;Bidani A;Heming T A;Awasthi S. Glutathione S-transferases of rabbit lung macrophages.. Toxicology and Applied Pharmacology. 148(2): 229-36, Feb 1998
17. Bidani A;Wang C Z;Saggi S J;Heming T A. Evidence for pH sensitivity of tumor necrosis factor-alpha release by alveolar macrophages.. Lung. 176(2): 111-21, 1998
18. Bidani A;Heming T A. Effects of concanavalin A on Na(+)-dependent and Na(+)-independent mechanisms for
    H+ extrusion in alveolar macrophages.. Lung. 176(1): 25-34, 1998
19. Bidani A;Wang C Z;Heming T A. Cotton smoke inhalation primes alveolar macrophages for tumor necrosis factor-alpha production and suppresses macrophage antimicrobial activities.. Lung. 176(5): 325-36, 1998
20. Brunston R L Jr;Zwischenberger J B;Tao W;Cardenas V J Jr;Traber D L;Bidani A. Total arteriovenous CO2 removal: simplifying extracorporeal support for respiratory failure [see comments]. Annals of Thoracic Surgery. 64(6): 1599-604; discussion, Dec 1997
21. Brunston R L Jr;Tao W;Bidani A;Alpard S K;Traber D L;Zwischenberger J B. Prolonged hemodynamic stability during arteriovenous carbon dioxide removal for severe respiratory failure.. Journal of Thoracic and Cardiovascular Surgery. 114(6): 1107-14, Dec 1997
22. Brunston R L Jr;Tao W;Bidani A;Traber D L;Zwischenberger J B. Organ blood flow during arteriovenous carbon dioxide removal.. Asaio Journal. 43(5): M821-4, Sep 1997
23. Frank B R;Tao W;Brunston R L Jr;Alpard S K;Bidani A;Zwischenberger J B. High flow/low resistance cannulas for percutaneous arteriovenous carbon dioxide removal.. Asaio Journal. 43(5): M817-20, Sep 1997
24. Chung D C;Niranjan S C;Clark J W Jr;Bidani A;Johnston W E;Zwischenberger J B;Traber D L. A dynamic model of ventricular interaction and pericardial influence.. American Journal of Physiology. 272(6 Pt 2): H2942-62, Jun 1997
25. Tao W;Brunston R L Jr;Bidani A;Pirtle P;Dy J;Cardenas V J Jr;Traber D L;Zwischenberger J B. Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure.. Critical Care Medicine. 25(4): 689-95, Apr 1997
26. Bidani A;Heming T A. Effects of lidocaine on cytosolic pH regulation and stimulus-induced effector functions in alveolar macrophages.. Lung. 175(6): 349-61, 1997
27. Brunston R L Jr;Tao W;Bidani A;Cardenas V J Jr;Traber D L;Zwischenberger J B. Determination of low blood flow limits for arteriovenous carbon dioxide removal.. Asaio Journal. 42(5): M845-9, Sep 1996
28. Stabenau E K;Bidani A;Heming T A. Physiological characterization of pulmonary carbonic anhydrase in the turtle.. Respiration Physiology. 104(2-3): 187-96, Jul 1996
29. Zwischenberger J B;Tao W;Bidani A. Advances in the management of respiratory failure. Intracorporeal membrane gas exchange: will it still prevail?. Asaio Journal. 42(3): 207-8, May 1996
30. Cardenas V J Jr;Zwischenberger J B;Tao W;Nguyen P D;Schroeder T;Traber L D;Traber D L;Bidani A. Correction of blood pH attenuates changes in hemodynamics and organ blood flow during permissive hypercapnia.. Critical Care Medicine. 24(5): 827-34, May 1996
31. Bidani A;Wang C Z;Heming T A. Early effects of smoke inhalation on alveolar macrophage functions.. Burns. 22(2): 101-6, Mar 1996
32. Bidani A;Zwischenberger J B;Cardenas V. Intracorporeal gas exchange: current status and future development [editorial]. Intensive Care Medicine. 22(2): 91-3, Feb 1996
33. Brunston Robert L;Tao Weike;Bidani Akhil;Cardenas Victor J;Traber Daniel L;Zwischenberger Joseph B. Determination of low blood flow limits for arteriovenous carbon dioxide removal. ASAIO Journal. 24(5): M845-M849, 1996
34. Zwischenberger Joseph B;Tao Weike;Bidani Akhil. Advances in the management of respiratory failure - intracorporeal membrane gas exchange: Will it still prevail?. ASAIO Journal. 42(3): 207-208, 1996
35. Brunston Robert L;Tao Weike;Bidani Akhil;Cardenas Victor J;Traber Daniel L;Zwischenberger Joseph B. Determination of low blood flow limits for arteriovenous carbon dioxide removal. ASAIO Journal. 42(5): M845-M849, 1996
36. Bidani A;Brown S E;Heming T A. Cytosolic pH regulation in density-defined subpopulations of bronchoalveolar macrophages.. Lung. 174(4): 225-34, 1996
37. Postlethwait E M;Langford S D;Jacobson L M;Bidani A. NO2 reactive absorption substrates in rat pulmonary surface lining fluids.. Free Radical Biology and Medicine. 19(5): 553-63, Nov 1995
38. Heming T A;Traber D L;Hinder F;Bidani A. Effects of bafilomycin A1 on cytosolic pH of sheep alveolar and peritoneal macrophages: evaluation of the pH-regulatory role of plasma membrane V-ATPases.. Journal of Experimental Biology. 198 ( Pt 8): 1711-5, Aug 1995
39. Tao W;Bidani A;Cardenas V J Jr;Niranjan S C;Zwischenberger J B. Stragegies to reduce surface area requirements for carbon dioxide removal for an intravenacaval gas exchange device.. Asaio Journal. 41(3): M567-72, Jul 1995
40. Bidani A;Heming T A. Kinetic analysis of cytosolic pH regulation in alveolar macrophages:
    V-ATPase-mediated responses to a weak acid.. American Journal of Physiology. 269(1 Pt 1): L20-9, Jul 1995
41. Langford S D;Bidani A;Postlethwait E M. Ozone-reactive absorption by pulmonary epithelial lining fluid constituents.. Toxicology and Applied Pharmacology. 132(1): 122-30, May 1995
42. Heming T A;Bidani A. Na(+)-H+ exchange in resident alveolar macrophages: activation by osmotic cell shrinkage.. Journal of Leukocyte Biology. 57(4): 609-16, Apr 1995
43. Heming T A;Bidani A. Effects of myristate phorbol ester on V-ATPase activity and Na(+)-H+ exchange in alveolar macrophages.. Journal of Leukocyte Biology. 57(4): 600-8, Apr 1995
44. Bidani A;Heming T A. Effects of bafilomycin A1 on functional capabilities of LPS-activated alveolar macrophages.. Journal of Leukocyte Biology. 57(2): 275-81, Feb 1995
45. Zwischenberger J B;Cardenas V J Jr;Tao W;Niranjan S C;Clark J W;Bidani A. Intravascular membrane oxygenation and carbon dioxide removal with IVOX: can improved design and permissive hypercapnia achieve adequate respiratory support during severe respiratory failure?. Artificial Organs. 18(11): 833-9, Nov 1994
46. Conrad S A;Zwischenberger J B;Eggerstedt J M;Bidani A. In vivo gas transfer performance of the intravascular oxygenator in acute respiratory failure.. Artificial Organs. 18(11): 840-5, Nov 1994 Niranjan S C;Clark J W;San K Y;Zwischenberger J B;Bidani A. Analysis of factors affecting gas exchange in intravascular blood gas exchanger.. Journal of Applied Physiology. 77(4): 1716-30, Oct 1994
47. Bidani A;Tzouanakis A E;Cardenas V J Jr;Zwischenberger J B. Permissive hypercapnia in acute respiratory failure [see comments]. Jama. 272(12): 957-62, 28 Sep 1994
48. Heming T A;Stabenau E K;Vanoye C G;Moghadasi H;Bidani A. Roles of intra- and extracellular carbonic anhydrase in alveolar-capillary CO2 equilibration.. Journal of Applied Physiology. 77(2): 697-705, Aug 1994
49. Zwischenberger J B;Nguyen T T;Tao W;Bush P E;Cox C S;Traber D L;Herndon D N;Bidani A. IVOX with gradual permissive hypercapnia: a new management technique for respiratory failure.. Journal of Surgical Research. 57(1): 99-105, Jul 1994
50. Tao W;Schroeder T;Bidani A;Cardenas V J Jr;Nguyen P D;Bradford D W;Traber D L;Zwischenberger J B. Improved gas exchange performance of the intravascular oxygenator by active blood mixing.. Asaio Journal. 40(3): M527-32, Jul 1994
51. Bidani A;Brown S E;Heming T A. pHi regulation in alveolar macrophages: relative roles of Na(+)-H+ antiport and H(+)-ATPase.. American Journal of Physiology. 266(6 Pt 1): L681-8, Jun 1994
52. Tao W;Zwischenberger J B;Nguyen T T;Tzouanakis A E;Matheis E J;Traber D L;Bidani A. Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit.. Annals of Thoracic Surgery. 57(6): 1484-90; discussion, Jun 1994
53. Postlethwait E M;Bidani A. Mechanisms of pulmonary NO2 absorption.. Toxicology. 89(3): 217-37, 20 May 1994
54. Postlethwait E M;Langford S D;Bidani A. Determinants of inhaled ozone absorption in isolated rat lungs.. Toxicology and Applied Pharmacology. 125(1): 77-89, Mar 1994
55. Tao Weike;Schroeder Tyrus;Bidani Akhil;Cardenas Victor J;Nguyen Phuong-Dung J;Bradford Darien W;Traber Daniel L;Zwischenberger Joseph B. Improved gas exchange performance of the intravascular oxygenator by active blood mixing. ASAIO Journal. 40(3): M527-M532, 1994
56. Heming T A;Vanoye C G;Stabenau E K;Roush E D;Fierke C A;Bidani A. Inhibitor sensitivity of pulmonary vascular carbonic anhydrase.. Journal of Applied Physiology. 75(4): 1642-9, Oct 1993
57. Nguyen T T;Zwischenberger J B;Tao W;Traber D L;Herndon D N;Duncan C C;Bush P;Bidani A. Significant enhancement of carbon dioxide removal by a new prototype IVOX.. Asaio Journal. 39(3): M719-24, Jul 1993
58. Cox C S Jr;Zwischenberger J B;Graves D F;Niranjan S C;Bidani A. Intracorporeal CO2 removal and permissive hypercapnia to reduce airway pressure in acute respiratory failure. The theoretical basis for permissive hypercapnia with IVOX.. Asaio Journal. 39(2): 97-102, Apr 1993
59. Postlethwait E M;Langford S D;Bidani A. Kinetics of NO2 air space absorption in isolated rat lungs.. Journal of Applied Physiology. 73(5): 1939-45, Nov 1992
60. Zwischenberger J B;Cox C S;Graves D;Bidani A. Intravascular membrane oxygenation and carbon dioxide removal--a new application for permissive hypercapnia?. Thoracic and Cardiovascular Surgeon. 40(3): 115-20, Jun 1992
61. Heming T A;Bidani A. Influence of proton availability on intracapillary CO2-HCO3(-)-H+ reactions in isolated rat lungs.. Journal of Applied Physiology. 72(6): 2140-8, Jun 1992
62. Keeney S E;Cress S E;Brown S E;Bidani A. The effect of hyperoxic exposure on antioxidant enzyme activities of alveolar type II cells in neonatal and adult rats.. Pediatric Research. 31(5): 441-4, May 1992
63. Brown S E;Heming T A;Benedict C R;Bidani A. ATP-sensitive Na(+)-H+ antiport in type II alveolar epithelial cells.. American Journal of Physiology. 261(6 Pt 1): C954-63, Dec 1991
64. Postlethwait E M;Langford S D;Bidani A. Interfacial transfer kinetics of NO2 into pulmonary epithelial lining fluid.. Journal of Applied Physiology. 71(4): 1502-10, Oct 1991
65. Bidani A;Heming T A. Effects of perfusate buffer capacity on capillary CO2-HCO3(-)-H+ reactions: theory.. Journal of Applied Physiology. 71(4): 1460-8, Oct 1991
66. Postlethwait E M;Langford S D;Bidani A. Transfer of NO2 through pulmonary epithelial lining fluid.. Toxicology and Applied Pharmacology. 109(3): 464-71, Jul 1991
67. Bidani A. Analysis of abnormalities of capillary CO2 exchange in vivo.. Journal of Applied Physiology. 70(4): 1686-99, Apr 1991
68. DuBose T D Jr;Bidani A;Caflisch C R;Gennari F J;Maddox D A;Deen W M. Comment on PCO2 in renal cortex [letter; comment]. American Journal of Physiology. 260(4 Pt 2): F608-12, Apr 1991
69. Heming T A;Bidani A. In situ characterization of carbonic anhydrase activity in isolated rat lungs.. Journal of Applied Physiology. 69(6): 2155-62, Dec 1990
70. Postlethwait E M;Bidani A;Evans M J. The effect of NO2 exposure on perfusate distribution in isolated rat lungs: pulmonary versus bronchial circulation.. Toxicology and Applied Pharmacology. 106(3): 456-61, Dec 1990
71. Heming T A;Vanoye C G;Bidani A. Dipyridamole inhibition of HCO3(-)-Cl- exchange in human erythrocytes.. Journal of Pharmacology and Experimental Therapeutics. 255(2): 631-5, Nov 1990
72. Bidani A;Brown S E. ATP-dependent pHi recovery in lung macrophages: evidence for a plasma membrane H(+)-ATPase.. American Journal of Physiology. 259(4 Pt 1): C586-98, Oct 1990
73. Postlethwait E M;Langford S D;Bidani A. Reactive absorption of nitrogen dioxide by pulmonary epithelial lining fluid.. Journal of Applied Physiology. 69(2): 523-31, Aug 1990
74. Postlethwait E M;Bidani A. Reactive uptake governs the pulmonary air space removal of inhaled nitrogen dioxide.. Journal of Applied Physiology. 68(2): 594-603, Feb 1990
75. Heming T A;Vanoye C G;Brown S E;Bidani A. Cytoplasmic pH recovery in acid-loaded haemocytes of squid (Sepioteuthis lessoniana).. Journal of Experimental Biology. 148: 385-94, Jan 1990
76. Bidani A;Brown S E;Heming T A;Gurich R;Dubose T D Jr. Cytoplasmic pH in pulmonary macrophages: recovery from acid load is Na+ independent and NEM sensitive.. American Journal of Physiology. 257(1 Pt 1): C65-76, Jul 1989

› back to top