Chemical & Biomolecular Engineering

Top 20 Doctoral Program—National Research Council

Location

Dept. of Chemical & Biomolecular Engineering
University of Houston
S222 Engineering Bldg 1,
Houston, TX 77204-4004
Phone: 713-743-4300
Campus Map

Faculty

Dr. Akhil Bidani

Professor of Biomedical Engineering
Professor of Chemical & Biomolecular Engineering

Office Location: W206, Engineering Building 2

Tel: (713) 743-4066 | Fax: (713) 743-4323

Email: abidani [at] uh [dot] edu

Website: http://bme.egr.uh.edu/faculty/bidani/main

Education

  • B.S. Chemical Engineering, Punjab University (1969)
  • Ph.D. Chemical Engineering, University of Houston (1975)
  • M.D., University of Texas Medical Branch (1981)

Research Interests

Dr. Akhil Bidani's research interests include mechanisms and kinetics of microvascular gas and ion transport; intracellular pH and its regulation in lung cells; mechanisms of pulmonary uptake of toxic reactive gases; pathophysiology of lung function abnormalities in acute lung injury and ARDS; physiology of cardiopulmonary support; and mathematical modeling of cellular transport processes.

  • Mechanisms and kinetics of microvascular gas and ion transport
  • Intracellular pH and its regulation in lung cells
  • Mechanisms of pulmonary uptake of toxic reactive gases
  • Pathophysiology of lung function abnormalities in acute lung injury and ARDS
  • Physiology of cardiopulmonary support
  • Mathematical modeling of cellular transport processes

Funding Received

  • National Institutes of Health (NIH), 1 R01 HL51421-01A2, ALVEOLAR MACROPHAGE INTRACELLULAR ACID BASE REGULATION AND CELL FUNCTION, $228932, 1995-1999

Professional Activities

  • American Academy of Sleep Medicine
  • American Association for Bronchology
  • American Association for Respiratory Care
  • American College of Chest Physicians
  • American College of Critical Care Medicine
  • American College of Physicians
  • American Heart Association, Cardiopulmonary Council
  • American Institute of Chemical Engineering
  • American Medical Association
  • American Physiological Society
  • American Society for Artifical Internal Organs
  • American Society of Clinical Investigation
  • American Thoracic Society
  • Biomedical Engineering Society
  • European Society for Respiratory Physiology
  • Foundation for Critical Care
  • Galveston County Medical Association
  • Houston Society for Engineering in Medicine and Biology
  • New York Academy of Sciences
  • Society for Computer Simulation (SCS)
  • Society for Critical Care Medicine
  • Society for Leukocyte Biology
  • Society of General Physiologists
  • Southern Society for Clinical Investigation
  • Texas Medical Association
  • Texas Thoracic Society
  • World Association for Bronchology

Selected Publications

  1. Jayroe JB, Wang D, Deyo DJ, Alpard SK, Bidani A, Zwischenberger JB,

    “The effect of augmented hemodynamics on blood flow during arteriovenous carbon dioxide removal,” Asaio Journal (American Society for Artificial Internal Organs : 1992). 49(1): 30-4

    , 2003
  2. Heming TA, Bidani A,

    “Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange,” Immunobiology. 207(2): 141-8

    , 2003
  3. Badar T, Bidani A,

    “Mechanical ventilatory support,” Chest Surgery Clinics of North America, 12(2): 265-99, vi

    , 2002
  4. Heming TA, Bidani A,

    “Plasmalemmal H+ extruders in mammalian alveolar macrophages,” Comparative Biochemistry and Physiology. A: Molecular and Integrative Physiology, 133(1): 143-50

    , 2002
  5. Morrison RJ, Bidani A,

    “Acute respiratory distress syndrome epidemiology and pathophysiology,” Chest Surgery Clinics of North America, 12(2): 301-23

    , 2002
  6. Alpard SK; Duarte AG; Bidani A; Zwischenberger JB,

    “Pathogenesis and management of respiratory insufficiency following pulmonary resection,” Seminars in Surgical Oncology, 18(2): 183-96

    , 2000
  7. Alpard SK; Zwischenberger JB; Tao W; Deyo DJ; Bidani A,

    “Reduced ventilator pressure and improved P/F ratio during percutaneous arteriovenous carbon dioxide removal for severe respiratory failure,” Annals of Surgery, 230(2): 215-24

    , 1999
  8. Bidani A; Hawkins HK; Wang CZ; Heming TA,

    “Dose dependence and time course of smoke inhalation injury in a rabbit model,” Lung, 177(2): 111-22

    , 1999
  9. Niranjan SC; Bidani A; Ghorbel F; Zwischenberger JB; Clark JW Jr,

     “Theoretical study of inspiratory flow waveforms during mechanical ventilation on pulmonary blood flow and gas exchange,” Comput Biomed Res., 32(4): 355-90

    , 1999
  10. Zwischenberger JB; Alpard SK; Bidani A,

    “Early complications. Respiratory failure,” Chest Surgery Clinics of North America, 9(3): 543-64, viii,

    , 1999
  11. Zwischenberger JB; Alpard SK; Conrad SA; Johnigan RH; Bidani A,

    “Arteriovenous carbon dioxide removal: development and impact on ventilator management and survival during severe respiratory failure,” Perfusion, 14(4): 299-310

    , 1999
  12. Zwischenberger JB; Conrad SA; Alpard SK; Grier LR; Bidani A,

    “Percutaneous extracorporeal arteriovenous CO2 removal for severe respiratory failure,” Annals of Thoracic Surgery, 68(1): 181-7

    , 1999
  13. Zwischenberger JB; Tao W; Bidani A,

    “Intravascular membrane oxygenator and carbon dioxide removal devices: a review of performance and improvements,” ASAIO Journal, 45(1): 41-6

    , 1999
  14. Alpard S K; Bidani A; Conrad S A; Zwischenberger J B,

    “Arteriovenous carbon dioxide removal,” Asaio Journal, 44(3): 223-4

    , 1998
  15. Bidani A; Heming T A,

    “Effects of concanavalin A on Na(+)-dependent and Na(+)-independent mechanisms for H+ extrusion in alveolar macrophages,” Lung, 176(1): 25-34

    , 1998
  16. Bidani A; Wang C Z; Heming T A,

    “Cotton smoke inhalation primes alveolar macrophages for tumor necrosis factor-alpha production and suppresses macrophage antimicrobial activities,” Lung, 176(5): 325-36

    , 1998
  17. Bidani A; Wang C Z; Saggi S J; Heming T A,

    “Evidence for pH sensitivity of tumor necrosis factor-alpha release by alveolar macrophages,” Lung, 176(2): 111-21

    , 1998
  18. Cardenas V Jr; Heming T A; Bidani A,

    “Kinetics of CO2 excretion and intravascular pH disequilibria during carbonic anhydrase inhibition,” Journal of Applied Physiology, 84(2): 683-94

    , 1998
  19. Liu C H; Niranjan S C; Clark J W Jr; San K Y; Zwischenberger J B; Bidani A,

    “Airway mechanics, gas exchange, and blood flow in a nonlinear model of the normal human lung,” Journal of Applied Physiology, 84(4): 1447-69

    , 1998
  20. Morrison R J; Singhal S S; Bidani A; Heming T A; Awasthi S,

    “Glutathione S-transferases of rabbit lung macrophages,” Toxicology and Applied Pharmacology, 148(2): 229-36

    , 1998
  21. Bidani A; Heming T A,

    “Effects of lidocaine on cytosolic pH regulation and stimulus-induced effector functions in alveolar macrophages,” Lung, 175(6): 349-61

    , 1997
  22. Brunston R L Jr; Tao W; Bidani A; Alpard S K; Traber D L; Zwischenberger J B,

    “Prolonged hemodynamic stability during arteriovenous carbon dioxide removal for severe respiratory failure,” Journal of Thoracic and Cardiovascular Surgery, 114(6): 1107-14

    , 1997
  23. Brunston R L Jr; Tao W; Bidani A; Traber D L; Zwischenberger J B,

    “Organ blood flow during arteriovenous carbon dioxide removal,” Asaio Journal, 43(5): M821-4

    , 1997
  24. Brunston R L Jr; Zwischenberger J B; Tao W;Cardenas V J Jr; Traber D L; Bidani A,

    “Total arteriovenous CO2 removal: simplifying extracorporeal support for respiratory failure [see comments],” Annals of Thoracic Surgery, 64(6): 1599-604; discussion

    , 1997
  25. Chung D C; Niranjan S C; Clark J W Jr; Bidani A; Johnston W E; Zwischenberger J B; Traber D L,

    “A dynamic model of ventricular interaction and pericardial influence,” American Journal of Physiology, 272(6 Pt 2): H2942-62

    , 1997
  26. Frank B R; Tao W; Brunston R L Jr; Alpard S K; Bidani A; Zwischenberger J B,

    “High flow/low resistance cannulas for percutaneous arteriovenous carbon dioxide removal,” Asaio Journal, 43(5): M817-20

    , 1997
  27. Tao W; Brunston R L Jr; Bidani A; Pirtle P; Dy J; Cardenas V J Jr; Traber D L; Zwischenberger J B,

    “Significant reduction in minute ventilation and peak inspiratory pressures with arteriovenous CO2 removal during severe respiratory failure,” Critical Care Medicine, 25(4): 689-95

    , 1997
  28. Bidani A; Brown S E; Heming T A,

    “Cytosolic pH regulation in density-defined subpopulations of bronchoalveolar macrophages,” Lung, 174(4): 225-34

    , 1996
  29. Bidani A; Wang C Z; Heming T A,

    “Early effects of smoke inhalation on alveolar macrophage functions,” Burns, 22(2): 101-6

    , 1996
  30. Bidani A; Zwischenberger J B; Cardenas V,

    “Intracorporeal gas exchange: current status and future development [editorial],” Intensive Care Medicine, 22(2): 91-3

    , 1996
  31. Brunston R L Jr; Tao W; Bidani A; Cardenas V J Jr; Traber D L; Zwischenberger J B,

    “Determination of low blood flow limits for arteriovenous carbon dioxide removal,” Asaio Journal, 42(5): M845-9

    , 1996
  32. Brunston Robert L; Tao Weike; Bidani Akhil; Cardenas Victor J; Traber Daniel L; Zwischenberger Joseph B,

    “Determination of low blood flow limits for arteriovenous carbon dioxide removal,” ASAIO Journal, 24(5): M845-M849

    , 1996
  33. Brunston Robert L; Tao Weike; Bidani Akhil; Cardenas Victor J; Traber Daniel L; Zwischenberger Joseph B.,

    “Determination of low blood flow limits for arteriovenous carbon dioxide removal,” ASAIO Journal, 42(5): M845-M849

    , 1996
  34. Cardenas V J Jr; Zwischenberger J B; Tao W; Nguyen P D; Schroeder T; Traber L D; Traber D L; Bidani A,

    “Correction of blood pH attenuates changes in hemodynamics and organ blood flow during permissive hypercapnia,” Critical Care Medicine, 24(5): 827-34

    , 1996
  35. Stabenau E K; Bidani A; Heming T A,

    “Physiological characterization of pulmonary carbonic anhydrase in the turtle,” Respiration Physiology, 104(2-3): 187-96

    , 1996
  36. Zwischenberger J B; Tao W; Bidani A,

    “Advances in the management of respiratory failure. Intracorporeal membrane gas exchange: will it still prevail?” Asaio Journal, 42(3): 207-8

    , 1996
  37. Zwischenberger Joseph B; Tao Weike; Bidani Akhil,

    “Advances in the management of respiratory failure - intracorporeal membrane gas exchange: Will it still prevail?” ASAIO Journal, 42(3): 207-208

    , 1996
  38. Bidani A; Heming T A,

    “Kinetic analysis of cytosolic pH regulation in alveolar macrophages: V-ATPase-mediated responses to a weak acid,” American Journal of Physiology, 269(1 Pt 1): L20-9

    , 1995
  39. Bidani A; Heming T A,

    “Effects of bafilomycin A1 on functional capabilities of LPS-activated alveolar macrophages,” Journal of Leukocyte Biology, 57(2): 275-81

    , 1995
  40. Heming T A; Bidani A,

    “Na(+)-H+ exchange in resident alveolar macrophages: activation by osmotic cell shrinkage,” Journal of Leukocyte Biology, 57(4): 609-16

    , 1995
  41. Heming T A; Bidani A,

    “Effects of myristate phorbol ester on V-ATPase activity and Na(+)-H+ exchange in alveolar macrophages,” Journal of Leukocyte Biology, 57(4): 600-8

    , 1995
  42. Heming T A; Traber D L; Hinder F; Bidani A,

    “Effects of bafilomycin A1 on cytosolic pH of sheep alveolar and peritoneal macrophages: evaluation of the pH-regulatory role of plasma membrane V-ATPases,” Journal of Experimental Biology, 198 (Pt 8): 1711-5

    , 1995
  43. Langford S D; Bidani A; Postlethwait E M,

    “Ozone-reactive absorption by pulmonary epithelial lining fluid constituents,” Toxicology and Applied Pharmacology, 132(1): 122-30

    , 1995
  44. Postlethwait E M; Langford S D; Jacobson L M; Bidani A,

    “NO2 reactive absorption substrates in rat pulmonary surface lining fluids,” Free Radical Biology and Medicine, 19(5): 553-63

    , 1995
  45. Tao W; Bidani A; Cardenas V J Jr; Niranjan S C; Zwischenberger J B,

    “Stragegies to reduce surface area requirements for carbon dioxide removal for an intravenacaval gas exchange device,” Asaio Journal, 41(3): M567-72

    , 1995
  46. Bidani A; Brown S E; Heming T A,

    “pHi regulation in alveolar macrophages: relative roles of Na(+)-H+ antiport and H(+)-ATPase,” American Journal of Physiology, 266(6 Pt 1): L681-8

    , 1994
  47. Bidani A; Tzouanakis A E; Cardenas V J Jr; Zwischenberger J B,

    “Permissive hypercapnia in acute respiratory failure [see comments],” Jama, 272(12): 957-62, 28

    , 1994
  48. Conrad S A; Zwischenberger J B; Eggerstedt J M; Bidani A,

    “In vivo gas transfer performance of the intravascular oxygenator in acute respiratory failure,” Artificial Organs, 18(11): 840-5

    , 1994
  49. Heming T A; Stabenau E K; Vanoye C G; Moghadasi H; Bidani A,

    “Roles of intra- and extracellular carbonic anhydrase in alveolar-capillary CO2 equilibration,” Journal of Applied Physiology, 77(2): 697-705

    , 1994
  50. Niranjan S C; Clark J W; San K Y; Zwischenberger J B; Bidani A,

    “Analysis of factors affecting gas exchange in intravascular blood gas exchanger,” Journal of Applied Physiology, 77(4): 1716-30

    , 1994
  51. Postlethwait E M; Bidani A,

    “Mechanisms of pulmonary NO2 absorption,” Toxicology, 89(3): 217-37

    , 1994
  52. Postlethwait E M; Langford S D; Bidani A,

    “Determinants of inhaled ozone absorption in isolated rat lungs,” Toxicology and Applied Pharmacology, 125(1): 77-89

    , 1994
  53. Tao W; Schroeder T; Bidani A; Cardenas V J Jr; Nguyen P D; Bradford D W; Traber D L; Zwischenberger J B,

    “Improved gas exchange performance of the intravascular oxygenator by active blood mixing,” Asaio Journal, 40(3): M527-32

    , 1994
  54. Tao W; Zwischenberger J B; Nguyen T T; Tzouanakis A E; Matheis E J; Traber D L; Bidani A,

    “Performance of an intravenous gas exchanger (IVOX) in a venovenous bypass circuit,” Annals of Thoracic Surgery, 57(6): 1484-90; discussion

    , 1994
  55. Tao Weike; Schroeder Tyrus; Bidani Akhil; Cardenas Victor J; Nguyen Phuong-Dung J; Bradford Darien W; Traber Daniel L; Zwischenberger Joseph B,

    “Improved gas exchange performance of the intravascular oxygenator by active blood mixing,” ASAIO Journal, 40(3): M527-M532

    , 1994
  56. Zwischenberger J B; Cardenas V J Jr; Tao W; Niranjan S C; Clark J W; Bidani A,

    “Intravascular membrane oxygenation and carbon dioxide removal with IVOX: can improved design and permissive hypercapnia achieve adequate respiratory support during severe respiratory failure?” Artificial Organs, 18(11): 833-9

    , 1994
  57. Zwischenberger J B; Nguyen T T; Tao W; Bush P E; Cox C S; Traber D L; Herndon D N; Bidani A,

    “IVOX with gradual permissive hypercapnia: a new management technique for respiratory failure,” Journal of Surgical Research, 57(1): 99-105

    , 1994
  58. Cox C S Jr; Zwischenberger J B; Graves D F; Niranjan S C; Bidani A,

    “Intracorporeal CO2 removal and permissive hypercapnia to reduce airway pressure in acute respiratory failure. The theoretical basis for permissive hypercapnia with IVOX,” Asaio Journal, 39(2): 97-102

    , 1993
  59. Heming T A; Vanoye C G; Stabenau E K; Roush E D; Fierke C A; Bidani A,

    “Inhibitor sensitivity of pulmonary vascular carbonic anhydrase,” Journal of Applied Physiology, 75(4): 1642-9

    , 1993
  60. Nguyen T T; Zwischenberger J B; Tao W; Traber D L; Herndon D N; Duncan C C; Bush P; Bidani A,

    “Significant enhancement of carbon dioxide removal by a new prototype IVOX,” Asaio Journal, 39(3): M719-24

    , 1993
  61. Heming T A; Bidani A.,

    "Influence of proton availability on intracapillary CO2-HCO3(-)-H+ reactions in isolated rat lungs," Journal of Applied Physiology, 72(6): 2140-8

    , 1992
  62. Keeney S E; Cress S E; Brown S E; Bidani A.,

    "The effect of hyperoxic exposure on antioxidant enzyme activities of alveolar type II cells in neonatal and adult rats," Pediatric Research, 31(5): 441-4

    , 1992
  63. Postlethwait E M; Langford S D; Bidani A.,

    "Kinetics of NO2 air space absorption in isolated rat lungs," Journal of Applied Physiology, 73(5): 1939-45

    , 1992
  64. Zwischenberger J B; Cox C S; Graves D; Bidani A.,

    "Intravascular membrane oxygenation and carbon dioxide removal--a new application for permissive hypercapnia?" Thoracic and Cardiovascular Surgeon, 40(3): 115-20

    , 1992
  65. Bidani A.,

    "Analysis of abnormalities of capillary CO2 exchange in vivo," Journal of Applied Physiology, 70(4): 1686-99

    , 1991
  66. Bidani A; Heming T A.,

    "Effects of perfusate buffer capacity on capillary CO2-HCO3(-)-H+ reactions: theory," Journal of Applied Physiology, 71(4): 1460-8

    , 1991
  67. Brown S E; Heming T A; Benedict C R; Bidani A.,

    "ATP-sensitive Na(+)-H+ antiport in type II alveolar epithelial cells," American Journal of Physiolog, 261(6 Pt 1): C954-63

    , 1991
  68. DuBose T D Jr; Bidani A; Caflisch C R; Gennari F J; Maddox D A; Deen W M.,

    "Comment on PCO2 in renal cortex [letter; comment]," American Journal of Physiology, 260(4 Pt 2): F608-12

    , 1991
  69. Postlethwait E M; Langford S D; Bidani A.,

    "Interfacial transfer kinetics of NO2 into pulmonary epithelial lining fluid," Journal of Applied Physiology, 71(4): 1502-10

    , 1991
  70. Postlethwait E M; Langford S D; Bidani A.,

    "Transfer of NO2 through pulmonary epithelial lining fluid," Toxicology and Applied Pharmacology, 109(3): 464-71

    , 1991
  71. Bidani A; Brown S E.,

    "ATP-dependent pHi recovery in lung macrophages: evidence for a plasma membrane H(+)-ATPase," American Journal of Physiology, 259(4 Pt 1): C586-98

    , 1990
  72. Heming T A; Bidani A.,

    "In situ characterization of carbonic anhydrase activity in isolated rat lungs," Journal of Applied Physiology, 69(6): 2155-62

    , 1990
  73. Heming T A; Vanoye C G; Bidani A.,

    "Dipyridamole inhibition of HCO3(-)-Cl- exchange in human erythrocytes," Journal of Pharmacology and Experimental Therapeutics, 255(2): 631-5

    , 1990
  74. Heming T A; Vanoye C G; Brown S E; Bidani A.,

    "Cytoplasmic pH recovery in acid-loaded haemocytes of squid (Sepioteuthis lessoniana)," Journal of Experimental Biology, 148: 385-94

    , 1990
  75. Postlethwait E M; Bidani A.,

    "Reactive uptake governs the pulmonary air space removal of inhaled nitrogen dioxide," Journal of Applied Physiology, 68(2): 594-603

    , 1990
  76. Postlethwait E M; Bidani A; Evans M J.,

    "The effect of NO2 exposure on perfusate distribution in isolated rat lungs: pulmonary versus bronchial circulation," Toxicology and Applied Pharmacology, 106(3): 456-61

    , 1990
  77. Postlethwait E M; Langford S D; Bidani A.,

    "Reactive absorption of nitrogen dioxide by pulmonary epithelial lining fluid," Journal of Applied Physiology. 69(2): 523-31

    , 1990
  78. Bidani A; Brown S E; Heming T A; Gurich R; Dubose T D Jr.,

    "Cytoplasmic pH in pulmonary macrophages: recovery from acid load is Na+ independent and NEM sensitive," American Journal of Physiology, 257(1 Pt 1): C65-76

    , 1989